October 12-17, 1997
Holiday Inn Lido Beijing
Beijing, China
Chairs:
Yao-Ting Yu
Nankai University
Gao-Xiang Li
Academia Sinica
Engineering Foundation Conferences
345 East 47th Street - Suite 303
New York, NY 10017
T: 1-212-70507835 - F: 1-212-705-7441
E: engfnd@aol.com - WWW: http://www.engfnd.org
SUNDAY, OCTOBER 12, 1997
15:00 - 18:00 Registration (Lobby of Holiday Inn Lido)
18:00 - 19:30 Dinner
19:30 - 21:00 OPENING SESSION AND CONFERENCE OVERVIEW
Yao-Ting Yu, Nankai University, China
Gao-Xiang Li, Institute of Microbiology, China
Allen Laskin, Engineering Foundation, USA
Barbara Hickernell, Engineering Foundation, USA
KEYNOTE ADDRESS
Comparison of Enzymes and Synzymes in Continuous Redox
Reactions
Christian Wandrey
Research Center Julich, Institute of Biotechnology, Germany
21:00 - 23:00 Opening Reception
MONDAY, OCTOBER 13, 1997
07:00 - 08:00 Breakfast Buffet
08:30 - 12:00 SESSION I: PROTEIN ENGINEERING OF INDUSTRIAL
RELEVANT ENZYMES
Session Chairs: K. Mosbach and C.C. Wang
08:30 - 09:15 Conformational Flexibility of Enzyme Active
Sites
Chen-Lu Tsou
Institute of Biophysics, Academia Sinica, Beijing, China
09:15 - 09:50 Optimization of Industrial Enzymes by Evolution
in the Laboratory
Frances Arnold
California Institute of Technology, Pasadena, CA, USA
09:50 - 10:15 Coffee Break
10:15 - 10:50 Protein Engineering of Superoxide Dismutase
Giuseppe Rotilio
Universita Degli Studi Di Roma, Italy
10:50 - 11:25 Cloning of x-Amylase Gene from Schwanniomyces
occidentalis and Expressing in Saccharomyces cerevisiae
Shu-Zheng Zhang
Institute of Microbiology, Academia Sinica, Beijing, China
11:25 - 12:00 Improving the Properties of Industrial Enzymes
by Protein Engineering
Jan Moller Mikkelsen
Novo Nordisk Biotechnology Co. Ltd., Copenhagen, Denmark
12:15 - 13:45 Lunch
Meeting of 1999 Enzyme Engineering Conference Committee
13:45 - 15:30 Ad hoc sessions/free time
15:30 - 17:30 POSTER SESSION I
17:30 - 19:30 Dinner
19:30 - 21:30 SESSION II: INDUSTRIAL BIOCATALYSIS
- CASE STUDIES
Session Chairs: A. Margolin and J.M. Mikkelson
19:30 - 20:15 Enzymatic Synthesis of Industrial Intermediates
and Products
David L. Anton
E.I. Dupont de Nemours Co., Wilmington, DE, USA
20:15 - 20:50 Industrial Production of Fructo-oligosaccharides
and Palatinoise by the Bioreactor Technology: Cheil Jedang's
Experiences
Yeong J. Jeon
Research & Development Center, Cheil Jedang Corp., Korea
20:50 - 21:25 Genetic Engineering Glucoamylase to Improve
Its Industrial Characteristics
Clark Ford
Iowa State University, USA
21:25 - 22:00 Protein Engineering of a Lipase from Humicola
Lanuginosa for Industrial Uses
Jens Sigurd Okkels
Novo Nordisk Bioindustry, Japan
22:00 Cash Bar
TUESDAY, OCTOBER 14, 1997
07:00 - 08:00 Breakfast Buffet
08:30 - 12:00 SESSION III: FINE CHEMICAL SYNTHESIS
USING ENZYMES
Session Chairs: J.S. Dordick and R. Matsuno
08:30 - 09:15 Combinatorial Biocatalysis
Yuri Khmelnitsky
EnzyMed, Inc., Iowa City, IA, USA
09:15 - 09:50 Enzymatic Synthesis of Chiral Lactones, Amines
and Alcohols
Arie L. Gutman
Technion-Israel Institute of Technology, Haifa, Israel
09:50 - 10:15 Coffee Break
10:15 - 10:50 Enzymatic Synthesis of Optically Pure D-Amino Acid using Thermostable D-Hydantoinase from Thermophilic Bacillus
10:50 - 11:25 Enzymatic Modification of Natural Compounds
with Pharmacological Properties
Sergio Riva
Instituto Di Chimica Degli Ormoni, C.N.R., Milan, Italy
11:25 - 12:00 Double Bond - Transferring Novel Hydroxylation
Reaction Involved in Microbial Metabolism of Plant Essential
Oil Eugenol
Toru Nagasawa
Okayama University, Japan
12:15 - 13:45 Lunch
Joint Meeting of 1997 Organizing Committee and Awards Committee
13:45 - 15:30 Ad hoc sessions/free time
15:30 - 17:30 POSTER SESSION II
17:30 - 19:30 Dinner
19:30 - 22:00 SESSION IV: ENZYMES IN BIOMATERIALS
AND MEDICINE
Session Chairs: A. Klibanov and I. Urabe
19:30 - 20:15 Novel Crystalline Catalysts
Alex Margolin
Altus Biologics Inc., Cambridge, MA, USA
20:15 - 20:50 Tissue Engineering in Biomedical Applications
Yao-Ting Yu
Nankai University, Tianjin, China
20:50 - 21:25 New Strategy of Thrombolysis: Conjunctive Effect
of Plasminogen Activators with Different Pharmacologic Profiles
Alexander V. Maksimenko
Institute of Experimental Cardiology, Moscow, Russia
21:25 - 22:00 De Novo Biosynthesis of Metal Binding Catalytic
Sites: Structural Studies using Affinity Methods and Molecular
Modeling
M.A. Vijayalakshmi
Uni. Technol. de Compiegne, France
22:00 Cash Bar
WEDNESDAY, OCTOBER 15, 1997
07:00 - 08:00 Breakfast Buffet
08:30 - 12:00 SESSION V: ARTIFICIAL ENZYMES
Session Chairs: D. Clark and D. Thomas
08:30 - 09:15 Antiidiotype Catalytic Antibodies
Daniel Thomas
Universite de Compiegne, France
09:15 - 09:50 Towards Plastic Enzymes by Molecular Imprinting
- Where do We Stand Today?
Klaus Mosbach
University of Lund, Sweden
09:50 - 10:15 Coffee Break
10:15 - 10:50 Ribozyme-Mediated Resistance Against Viroid
and Virus in Transgenic Plants
Po Tien
Institute of Microbiology, Academia Sinica, Beijing, China
10:50 - 11:25 The Property of Artificial Random Proteins
Itaru Urabe
Osaka University, Japan
11:25 - 12:00 Generation of a Selenium-Containing Abzyme
by using Chemical Mutation of the Monoclonal Antibody with
Substrate Binding Sites
Gui-Min Luo
Jilin University, China
12:15 - 13:45 Lunch
13:45 - 15:30 Ad hoc sessions/free time
15:30 - 17:30 POSTER SESSION II
18:00 - 19:30 Dinner
19:30 - 22:15 SESSION VI: ENVIRONMENTAL BIOCATALYSIS
Session Chairs: T-C. Cheng and D. Cowan
19:30 - 20:15 Directed Evolution of New Enzymes and Pathways
for Environmental Biocatalysis
Lawrence P. Wackett
University of Minnesota, USA
20:15 - 20:50 Molecular Breeding of Polysaccharide-Utilizing
Yeast Cells by Cell Surface
Atsuo Tanaka
Kyoto University, Japan
20:50 - 21:25 Fighting Chemical Weapons with Enzyme Engineering
Alan J. Russell
University of Pittsburgh, PA, USA
21:25 - 22:15 POSTER REVIEW
22:15 Cash Bar
THURSDAY, OCTOBER 16, 1997
07:00 - 08:00 Breakfast
08:30 - 12:00 SESSION VII: ENZYMES UNDER EXTREME CONDITIONS
Session Chairs: A.L. Gutman and X-Z Zhang
08:30 - 09:15 Biocatalysis in the P-T Plane
Douglas S. Clark
University of California-Berkeley, USA
09:15 - 09:50 Biocatalysis and Biorecognition in Nonaqueous
Media
Jonathan Dordick
University of Iowa, USA
09:50 - 10:15 Coffee Break
10:15 - 10:50 Catalysis of Enzymes Dissolved (rather than
suspended) in Organic Solvents
Alexander M. Klivanov
Massachusetts Institute of Technology, Cambridge, MA, USA
10:50 - 11:25 The Stabilization of Horseradish Peroxidase
in Nonaqueous Media
Zhong-Yi Yuan
Shanghai Institute of Biochemistry, China
11:25 - 12:00 Multiple Intensified Performance of Enzyme-catalyzed
Reaction in Organic Media
Tsuneo Yamane
Nagoya University, Japan
12:15 - 13:15 Lunch
13:40 - 18:00 Optional Sightseeing Trip to the Great Wall
18:30 Banquet and Enzyme Engineering Award
FRIDAY, OCTOBER 17, 1997
07:00 - 08:30 Breakfast Buffet
08:30 - 12:00 SESSION VIII: ANALYTICAL APPLICATIONS
OF ENZYMES
Session Chairs: A.J. Russell and K. Yoda
08:30 - 09:15 TBA
Isao Karube
Tokyo University, Japan
09:15 - 09:50 New Recognition Elements in Biosensing
Frieder W. Scheller
Potsdam University, Berlin, Germany
09:50 - 10:15 Coffee Break
10:15 - 10:50 Engineered Proteins for Multi-Analytical Biosensors
Rolf D. Schmid
University of Stuttgart, Germany
10:50 - 11:25 Neural Networks as Software Sensors in Enzyme
Engineering
Pekko Linko
Helsinki University of Technology, Finland
11:25 - 12:00 Biosensors for Fermentation Process Control
Jianguo Liu
Institute of Microbiology, Academia Sinica, Beijing, China
12:15 Lunch and Adjournment