Sunday, July 13, 1997

03:00 pm Registration (Lobby of Cliff Lodge at Snowbird)

06:30 pm - 08:00 pm Opening Dinner

08:00 pm - 09:00 pm Welcoming by chairs

09:00 pm - 10:00 pm Opening Reception

Monday, July 14, 1997

07:00 am - 08:30 am Breakfast Buffet

08:30 am - 12:30 pm Session I:

Laser/Tissue Interactions

• therapeutic techniques with real time optical feedback
• therapeutic laser techniques: pulse or no pulse?
• biomolecular responses

Session Organizer:
Steve Jacques, Oregon Medical Laser Center
Introduction

Guy Delacretaz
Swiss Federal Institute of Technology, Lausanne
"Photothermal ablation of the zona pellucida."

Coffee Break

Randy Glickman
University of Texas Health Science Center at San Antonio
"Photochemical oxidation by ocular melanin stimulated by CW and short pulse laser exposures."

Duncan Maitland
Lawrence Livermore National Laboratory
"Photomechanical stress waves: shear and tensile stress fields generated by pulsed lasers."

12:30 pm - 02:00 pm Lunch

02:00 pm - 06:00 pm Ad hoc discussions/free time

05:30 pm - 07:00 pm Dinner

07:00 pm - 10:00 pm Session II:

Lasers in minimally invasive surgery

• new surgical applications of lasers (e.g., skin resurfacing)
• medical applications of lasers
• new applications of lasers in ophthalmology

Session organizer:
Yona Tadir, Medical Director, Beckman Laser Inst., UC Irvine

Stephen Bown
National Medical Laser Centre, University College London
"PDT and ILP (interstitial laser photocoagulation) for tumors in solid organs"

Rox Anderson
Wellman Laboratory, Harvard Medical School
Robert H. Webb
Massachusetts General Hospital,
"Lasers in your eye - have they delivered?"

10:00 pm - 11:00 pm Social Hour

Tuesday, July 15, 1997

07:00 am - 8:30 am Breakfast Buffet

08:30 am - 12:30 pm Session III:

Photodynamic therapy

• molecular mechanisms
• clinical applications

Session organizer:
Charles Gomer, University of Southern California

Industry Round Table:

1. Stuart Marcus, MD, Ph.D.
DUSA Pharmaceuticals, Ibc.
"Mechanisms and Developmental Status of Levulan (tm)(5 amino levulinic acid) PDT and Photodiagnosis (PD)"

2. Stuart Young, M.D.
Pharmacyclics Inc.
"Biomedical Applications of Texafrins in Disease Detection and Treatment"

3. Julia Levy, Ph.D.
QLT Phototherapeutics, Inc.
"Immuno modulatory Affects of Photodynamic Therapy"

4. David Crean, Ph.D.
PDT Inc.
"Molecular Mechanisms and Clinical Applications of SnET2 Photodynamic Therapy"

Coffee Break

The View From Academics:

Lars Svaasand, Ph.D.
University of Trondheim
"Dosimetry for Photodynamic Therapy; Light and Drug Distribution"

Tayyaba Hasan, Ph.D.
Massachusetts general Hospital and Harvard University
"Targeted Photodynamic Therapy"

Eli Glatstein, M.D.
University of Pennsylvania
"PDT Star Wars Against Cancer in the 21st Century"

12:30 pm - 02:00 pm Lunch

02:00 pm - 04:00 pm Ad hoc discussions/free time

04:00 pm - 06:00 pm Poster Session
(Poster presenters please be by your poster)

05:30 pm - 07:00 pm Dinner

07:00 pm - 10:00 pm Session IV:

New optical techniques in medicine

• medical applications of laser based microscopies and novel biomolecular probes
• physiological imaging with OCT
• fluorescent optical reporters; bio luminescent optical reporters

Session organizer:
Daniel Farkas, Center for Light Microscopy and Imaging, Carnegie Mellon University

David Benaron
Stanford University
"Imaging Gene Expression and Brain Activation in the Body Using Light"

James Fujimoto
Massachusetts Institute of Technology,
"High Speed High Resolution Optical Coherence Tomography for Optical Biopsy"

Warren Zipfel
Cornell University
"Potential Applications of Multiphoton Microscopy in Medicine"

10:00 pm - 11:00 pm Social Hour

Wednesday, July 16, 1997

07:00 am - 08:30 am Breakfast Buffet

08:30 am - 12:30 pm Session V-A:

Optical spectroscopies in medicine

• Fluorescence, Raman, elastic scattering and photoacoustic methods:
• new approaches
• clinical results

Session organizers:
Michael Feld, Physics Dept., M.I.T.
Arjun Yodh, Physics Dept., University of Pennsylvania

David Boas
Tufts University
"Images of motions in highly scattering media with diffusing temporal correlation"

Lihong Wang
Texas A&M University
"Studies of Ultrasound Modulated Optical Tomography"

Coffee Break

Judith Mourant
Los Alamos National Laboratory
"Elastic Light Scattering Properties of Cancerous and Noncancerous Cells"

Ramasamy Manoharan
MIT
"Quantitative In Vivo Pathological Analysis of Colonic Dysplasia using Fluoresence and Reflectance Spectroscopy"

12:30 pm - 02:00 pm Lunch

02:00 pm - 04:00 pm Ad hoc discussions/free time

04:00 pm - 06:00 pm Poster Session
(Poster presenters please be by your poster)

05:30 pm - 07:00 pm Dinner

07:00 pm - 10:00 pm Session V-B:

Optical spectroscopies in medicine

• Elastic scattering and hybrid scattering techniques:
• scattering
• photo acoustic methods

Session organizers:
Michael Feld, Physics Dept., M.I.T.
Arjun Yodh, Physics Dept., U. Pennsylvania

Tom Foster
Department of Radiology, University of Rochester
"CW Spectroscopy and Imaging: Progress, Possibilities, and Problems"

Daniel Murnick
Department of Physics, Rutgers University, Newark
"Optical Spectroscopy for Diagnostic Breath Analysis"

Katarina Svanberg
Lund University, Sweden
"Spectroscopic methods in tumor therapy and tissue characterization."

Social Hour / Coffee Break

"The Optical Spectroscopy Quiz Show"
Panelists from morning & evening sessions V-A & V-B, + Mistery Guest

Hosts:
Arjun Yodh, Dept. of Physics, U. Pennsylvania
Michael Feld, MIT Spectroscopy Laboratory

Thursday, July 17, 1997

07:00 am - 08:30 am Breakfast Buffet

08:30 am - 12:30 pm Session VI:

Photon migration: clinical applications

• modeling of optical transport in tissue time dependent measurements in photon migration
• Coherent to diffuse domain: imaging and spectroscopy

Session organizer:
Mike Patterson, Hamilton Regional Cancer Centre and McMaster University

Enrico Gratton
Physics Department University of Illinois at Urbana Champaign
"Frequency domain measurements of muscle hemoglobin saturation during exercise"

Eva Sevick
Purdue University
"Photon migration for particle sizing in the chemical and pharmaceutical industries"

Coffee Break

Jeremy Hebden
University College London
"Optical tomography with the UCL multichannel time resolved imaging system"

Xingde Li
University of Pennsylvania
"Fast diffraction tomography for biomedical imaging with diffusive waves"

12:30 pm - 02:00 pm Lunch

02:00 pm - 05:00 pm Ad hoc discussions/free time

05:00 pm - 06:00 pm Social Hour

06:00 pm - 08:00 pm Conference Banquet

Plenary Banquet Speaker
Britton Chance
University of Pennsylvania:
"Shedding Light on Cytochromes: The Discovery of Energy linked Functions of Mitochondria"

08:00 pm - 10:30 pm Session VII:

Regulatory matters & industrial market perceptions

• new FDA guidelines on laser exposure ?
• industrial perspective: where's the market?

Session organizer:
Woody Ediger

Susan Alpert, PhD, MD,
Director Office of Device Evaluation
Center for Devices & Radiological Health
Food & Drug Administration
"From Idea to Market: the FDA Perspective"

J. Patrick Fitch, Ph.D.
Lawrence Livermore National Laboratory
"Collaborative Conversion of Technical Concepts to Medical Devices"

Thomas Baer, Ph.D.
Arcturus Engineering Inc.
"Commercializing Biomedical Technologies: A Small Company Perspective"

10:30 pm - 11:30 pm Closing Social Hour

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