Celebrating 50 years of international, interdisciplinary engineering
General Information and Fees
Biology, Engineering and Development
An ECI Conference
October 7-11, 2012
Merck Poster Award Winners
Poster Board Dimensions are 1.5 meters x 1.5 meters
Schloss Hernstein (the conference hotel) is fully booked.
New registration will be in nearby accommodations.
About This Conference
Dr. Steve Dowdy, UCSD School of Medicine, USA
Dr. Laura Sepp-Lorenzino, RNA Therapeutics, Merck & Co, Inc., USA
Dr. Gilles Divita, Université Montpellier, France
Dr. Marino Zerial, Max Planck Institute, Dresden, Germany
Oligonucleotide technologies, such as siRNA, tap into endogenous, highly
conserved and specific catalytic mechanisms to efficiently regulate
gene expression. As such, they have the potential to enable the development
of novel therapeutic options for disease targets previously considered
un-druggable by conventional small molecule and biologics means. However,
despite the promise, clinical development has been hindered by the challenges
encountered by identifying and developing safe and efficacious delivery
Since its discovery in 1998, RNA silencing has attracted
much attention, with over 50,000 peer-reviewed publications, multiple
national and international conferences, and significant investment in
the biotech and large pharma with the goal of developing new siRNA-based
therapies. Despite the interest and investment this has proven to be
more difficult that first envisioned. It is widely recognized that there
are gaps in our basic understanding on how to best harness this technology
for therapeutic use.
The ECI Oligonucleotide Delivery conference will provide a forum for increasing our mechanistic understanding of oligonucleotide delivery biological processes, strategies for rational chemical design of therapeutic oligonucleotides and delivery vehicles, formulation strategies, bioengineering and process development solutions to scale-up and manufacturing, and highlight programs in clinical development.
The conference will bring together basic research biologists and pharmacologists, chemists, biophysicists, and engineers working in the field of antisense, RNA interference and microRNA, and nanotechnology.
Outline The session topics are:
- Delivery Strategies #1 - Lipid Nanoparticles and Polymer System
- Delivery Strategies #2 - siRNA Conjugates
- Delivery Strategies #3 - Oligonucleotide Chemistry and Formulation Approaches
- Delivery Strategies #4 - Targeted Delivery
- Biology of Oligonucleotide Delivery
- Plenary Talks
- Poster Sessions
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